Endocrine Abstracts

Introduction: Acromegaly is associated with an increased mortality in untreated patients. Recent papers suggest an improvement of survival in the last years.Aims: To assess mortality ratio and to identify prognostic factors associated with mortality in acromegaly in the last decade.Methods: 297 patients (186 F/111 M, mean age 49.8±0.7 years) with acromegaly admitted in a single Neuroendocrinology Department between Jan 2001 an...

Congenital hypopituitarism is a rare disease, occurring sporadically in the vast majority of cases, that is found more frequently in males. We are presenting the case of a 19 year old that addressed our clinic because of short stature and lack of development of secondary sexual traits. During the clinical assessment we found his height to be 146 cm, corresponding to -4.78 SDs, Tanner stage of pubertal development 1 and lack of apocrine axillary odor. The patient was inapetent ...

Introduction: The pathogenesis of pituitary adenomas is incompletely understood. It was recently demonstrated that mutations in AIP, a novel tumor suppressor gene, are causing the familial isolated pituitary adenoma syndrome. Although initial data suggested that AIP mutations are rare in non-familial cases, a recent study demonstrated an increased prevalence in young sporadic macroadenoma patients.Aim: To perform a systematic screening of AIP mutations i...

Introduction: Monoclonality of pituitary adenomas is an established fact. Still, there are exceptions and polyclonality may correlate with aggressive tumor behavior. In order to test association of clonality with pituitary adenoma characteristics in a series from Romania, we implemented a protocol for X-chromosome inactivation analysis at the androgen receptor (AR) locus (HUMARA) and validated it in a number of tumor samples.Objective: To establish and v...